Table 1.
Echocardiographic parameters in Txnip wild-type and C247S mice seven days after sham or MI surgeries.
Sham | MI | |||
---|---|---|---|---|
WT | C247S | WT | C247S | |
Echocardiography, n | 12 | 12 | 25 | 25 |
Heart rate, beats/min | 688 ± 16 | 720 ± 11 | 700 ± 10 | 709 ± 7 |
End-diastolic dimension, mm | 3.0 ± 0.1 | 3.0 ± 0.1 | 4.2 ± 0.1* | 3.9 ± 0.1† |
End-systolic dimension, mm | 1.1 ± 0.1 | 1.1 ± 0.1 | 3.0 ± 0.1* | 2.7 ± 0.1† |
Anterior wall thickness, mm | 0.6 ± 0.01 | 0.6 ± 0.02 | 0.4 ± 0.01* | 0.4 ± 0.01† |
Posterior wall thickness, mm | 0.6 ± 0.01 | 0.6 ± 0.01 | 0.5 ± 0.02** | 0.6 ± 0.01 |
Fractional shortening, % | 64 ± 2 | 64 ± 2 | 28 ± 1* | 29 ± 1† |
Left ventricular mass per body weight | 2.3 ± 0.1 | 2.6 ± 0.2 | 3.2 ± 0.2* | 3.0 ± 0.2 |
P < 0.01 or
P < 0.05 vs. wild-type (WT) sham,
P < 0.01 vs. C247S sham. P=N.S. between WT and C247S for any parameters.