Table 5.

Criteria for optimal timing of liberation from renal replacement therapy in anticipation of kidney recovery (RRT)

Readiness for de-escalation

Resolution of precipitating acute events

Reduction in acuity and improvement in multiorgan dysfunction

Capability to maintain metabolic, electrolyte, acid–base homeostasis by conservative therapy

Increasing urine output (> 400 ml/24 h)

Biomarker-guided attempt to discontinue RRT

Timed (6-h or 24-h) creatinine clearance > 15 ml/min

Diuretic-induced urine output > 2000 ml/min

Outcomes

Days off RRT

Short-term morbidity and mortality

Need for re-initiation of RRT (failure)

Assessment of the attempt

Success or failure