Table 4.

Equations to estimate median uACR from uPCR using 4-knots linear spline and the change in slope before and after the range of the knots

uPCR (mg/gCr)	In patients with lifestyle-related disease	Non-diabetes and diabetes	Non-diabetes	Diabetes
ln(median uACR)	1R; < 20	0.3719 × ln(uPCR) + 1.2232	0.2801 × ln(uPCR) + 1.4345	0.2210 × ln(uPCR) + 1.5706
	2R; 20 to < 60	0.6224 × ln(uPCR) + 0.4727	0.6804 × ln(uPCR) + 0.2352	0.8277 × ln(uPCR) − 0.2471
	3R; 60 to < 120	1.5483 × ln(uPCR)-3.3183	1.6581 × ln(uPCR)-3.7678	1.1957 × ln(uPCR) − 1.7535
	4R; 120 to < 350	1.1524 × ln(uPCR)-1.4229	1.1401 × ln(uPCR)-1.2878	1.0335 × ln(uPCR) − 0.9770
	5R; 350 to < 500	1.0269 × ln(uPCR)-0.6880	0.9986 × ln(uPCR)-0.4592	1.8136 × ln(uPCR) − 5.5472

	CE	SE	t	p > t	95%CI	CE	SE	t	p > t	95%CI	CE	SE	t	p > t	95%CI
Change in slope
1R vs 2R	0.25	0.52	0.48	0.64	− 0.80 to 1.30	0.40	0.52	0.77	0.45	− 0.65 to 1.45	0.61	0.86	0.70	0.49	− 1.14 to 2.36
2R vs 3R	0.93	0.38	2.43	0.02	0.16–1.69	0.98	0.38	2.58	0.01	0.21–1.74	0.37	0.63	0.58	0.56	− 0.91 to 1.65
3R vs 4R	− 0.40	0.29	− 1.38	0.17	− 0.97 to 0.18	− 0.52	0.29	− 1.81	0.08	− 1.09 to 0.06	-0.16	0.50	-0.33	0.75	− 1.17 to 0.85
4R vs 5R	− 0.13	0.18	-0.69	0.50	− 0.49 to 0.24	− 0.14	0.18	− 0.77	0.44	− 0.51 to 0.23	0.78	0.54	1.45	0.16	− 0.32 to 1.88

uACR urinary albumin-to-creatinine ratio; uPCR urinary protein-to-creatinine ratio, ln natural logarithm; CE coefficient; SE standard error; CI confidence interval, Unit of uPCR, mg/gCr; Unit of uACR, mg/gCr