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. 2021 Mar 3;25(7):727–750. doi: 10.1007/s10157-021-02027-6

Table 7.

Cut-off value (YI) of the uPCR and uACR distinguishing patients with normoalbuminuria (n = 93) and micro- and macroalbuminuria (n = 104) in non-diabetic patients

Test variables 1uPCR 2uPCR 3uPCR 1.2uPCR 2.3uPCR 1.3uPCR 1.2.3uPCR 1uACR 2uACR 3uACR
ROC curve area 0.854 0.894 0.873 0.912a 0.911b 0.904c 0.924d 0.945e 0.961f 0.941 g
Standard error 0.027 0.022 0.026 0.020 0.021 0.021 0.018 0.01598 0.012 0.017
p value  < 0.0001  < 0.0001  < 0.0001  < 0.0001  < 0.0001  < 0.0001  < 0.0001  < 0.0001  < 0.0001  < 0.0001
CO(YI)h 0.10 0.09 0.09 0.16 0.16 0.17 0.23 31 31 30
Sensitivity 0.66 0.76 0.76 0.85 0.85 0.84 0.88 0.91 0.91 0.89
Specificity 0.82 0.89 0.87 0.87 0.86 0.85 0.84 0.91 0.88 0.90

1, 2, 3 uPCR denote first, second, and third uPCR, respectively. 1.2uPCR, 2.3uPCR, 1,3uPCR each denote the sum of the two indicated uPCRs. 1.2.3uPCR denotes the sum of the three uPCRs. 1, 2, 3uACR denotes first, second, and third uACR, respectively

uACR, urinary albumin-to-creatinine ratio; uPCR, urinary protein-to-creatinine ratio, CO(YI), cut-off value using Youden's index by the receiver operating characteristics curve

avs. 1uPCR, p = 0.0005

bvs. 3uPCR, p = 0.005

cvs 3uPCR, p = 0.047

dvs. 1uPCR, p = 0.0005; vs. 2uPCR, p = 0.047; vs. 3uPCR, p = 0.003

evs. 1uPCR, p = 0.0002; vs. 2uPCR, p = 0.045; vs. 3uPCR, p = 0.020

fvs. 1uPCR, p = 0.0002; vs. 2uPCR, p = 0.001; vs. 3uPCR, p = 0.001; vs. 1.2UP, p = 0.018, vs. 2.3UP, p = 0.015; vs. 1.3UP, p = 0.013

gvs. 1uPCR, p = 0.004; vs. 3uPCR, p = 0.002

hUnit of uPCR, g/gCr; Unit of uACR, mg/gCr