Table 7.
Cut-off value (YI) of the uPCR and uACR distinguishing patients with normoalbuminuria (n = 93) and micro- and macroalbuminuria (n = 104) in non-diabetic patients
Test variables | 1uPCR | 2uPCR | 3uPCR | 1.2uPCR | 2.3uPCR | 1.3uPCR | 1.2.3uPCR | 1uACR | 2uACR | 3uACR |
---|---|---|---|---|---|---|---|---|---|---|
ROC curve area | 0.854 | 0.894 | 0.873 | 0.912a | 0.911b | 0.904c | 0.924d | 0.945e | 0.961f | 0.941 g |
Standard error | 0.027 | 0.022 | 0.026 | 0.020 | 0.021 | 0.021 | 0.018 | 0.01598 | 0.012 | 0.017 |
p value | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 |
CO(YI)h | 0.10 | 0.09 | 0.09 | 0.16 | 0.16 | 0.17 | 0.23 | 31 | 31 | 30 |
Sensitivity | 0.66 | 0.76 | 0.76 | 0.85 | 0.85 | 0.84 | 0.88 | 0.91 | 0.91 | 0.89 |
Specificity | 0.82 | 0.89 | 0.87 | 0.87 | 0.86 | 0.85 | 0.84 | 0.91 | 0.88 | 0.90 |
1, 2, 3 uPCR denote first, second, and third uPCR, respectively. 1.2uPCR, 2.3uPCR, 1,3uPCR each denote the sum of the two indicated uPCRs. 1.2.3uPCR denotes the sum of the three uPCRs. 1, 2, 3uACR denotes first, second, and third uACR, respectively
uACR, urinary albumin-to-creatinine ratio; uPCR, urinary protein-to-creatinine ratio, CO(YI), cut-off value using Youden's index by the receiver operating characteristics curve
avs. 1uPCR, p = 0.0005
bvs. 3uPCR, p = 0.005
cvs 3uPCR, p = 0.047
dvs. 1uPCR, p = 0.0005; vs. 2uPCR, p = 0.047; vs. 3uPCR, p = 0.003
evs. 1uPCR, p = 0.0002; vs. 2uPCR, p = 0.045; vs. 3uPCR, p = 0.020
fvs. 1uPCR, p = 0.0002; vs. 2uPCR, p = 0.001; vs. 3uPCR, p = 0.001; vs. 1.2UP, p = 0.018, vs. 2.3UP, p = 0.015; vs. 1.3UP, p = 0.013
gvs. 1uPCR, p = 0.004; vs. 3uPCR, p = 0.002
hUnit of uPCR, g/gCr; Unit of uACR, mg/gCr