Table 8.

Cut-off value (YI) of uPCR discriminating uACR ≥ 30 mg/gCr in patients with or without diabetes mellitus according to the age, sex, GFR category (n = 591)

Cause	Non-diabetes mellitus
Test variables		Age (years)		Sex		GFR category
	< 65	65 to < 80	≥ 80	Male	Female	G1-3a	G3b-4
n	201	228	162	372	219	375	216
n (uACR ≥ 30 mg/gCr)	108	108	98	187	127	185	129
ROC curve area	0.896	0.862	0.863	0.861	0.908	0.865	0.892
Standard error	0.022	0.026	0.030	0.020	0.021	0.020	0.022
p value	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001
CO(YI) (g/gCr)	0.09	0.09	0.08	0.09	0.09	0.09	0.10
Sensitivity	0.74	0.72	0.84	0.74	0.78	0.72	0.79
Specificity	0.91	0.92	0.80	0.87	0.94	0.91	0.89

Cause	Diabetes mellitus
Test variables		Age (years)		Sex		GFR category
	< 65	65 to < 80	≥ 80	Male	Female	G1-3a	G3b-4
n	123	153	42	210	108	249	69
n (uACR ≥ 30 mg/gCr)	56	81	32	105	64	117	52
ROC curve area	0.879	0.889	0.878	0.909	0.842	0.872	0.912
Standard error	0.033	0.029	0.069	0.022	0.037	0.025	0.036
p value	< 0.0001	< 0.0001	0.0004	< 0.0001	< 0.0001	< 0.0001	< 0.0001
CO(YI) (g/gCr)	0.06	0.07	0.08	0.07	0.11	0.07	0.07
Sensitivity	0.89	0.83	0.84	0.88	0.63	0.80	0.89
Specificity	0.76	0.85	0.90	0.87	1.00	0.84	0.77

uACR urinary albumin-to-creatinine ratio; uPCR urinary protein-to-creatinine ratio, CO(YI) cut-off value using Youden's index; GFR glomerular filtration rate