Table 9.

Cut-off value (YI) of 2nd uPCR discriminating normoalbuminuria and micro- and macroalbuminuria in patients with or without diabetes mellitus according to the age, sex, GFR category

	Non-diabetes mellitus
Test variables			Age (years)		Sex		GFR category
	All	< 65	65 to < 80	≥ 80	Male	Female	G1-3a	G3b-4
n	197	67	76	54	124	73	125	72
n (≥ microalbuminuria)	104	35	36	33	61	43	61	43
ROC curve area	0.894	0.949	0.876	0.829	0.893	0.902	0.917	0.840
Standard error	0.022	0.025	0.039	0.058	0.028	0.035	0.023	0.047
P value	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001
CO(YI) (g/gCr)	0.09	0.09	0.09	0.07	0.09	0.09	0.07	0.10
Sensitivity	0.76	0.83	0.69	0.85	0.77	0.74	0.85	0.74
Specificity	0.89	0.97	0.90	0.71	0.87	0.93	0.88	0.83

	Diabetes mellitus
Test variables			Age (years)		Sex		GFR category
	All	< 65	65 to < 80	≥ 80	Male	Female	G1-3a	G3b-4
n	106	41	51	14	70	36	83	23
n (≥ microalbuminuria)	55	19	25	11	33	22	39	16
ROC curve area	0.831	0.835	0.812	0.879	0.845	0.807	0.786	0.951
Standard error	0.040	0.065	0.062	0.100	0.049	0.072	0.051	0.043
p value	< 0.0001	0.0003	0.0001	0.0516	< 0.0001	0.0022	< 0.0001	0.0007
CO(YI) (g/gCr)	0.06	0.06	0.10	0.15	0.06	0.12	0.06	0.07
Sensitivity	0.86	0.90	0.68	0.73	0.91	0.59	0.80	1.00
Specificity	0.69	0.73	0.88	1.00	0.68	0.93	0.68	0.71

Microalbuminuria: urinary albumin-to-creatinine ratio 30–299 mg/gCr at least twice for 3 measurements

uPCR urinary protein-to-creatinine ratio, CO(YI) cut-off value using Youden's index; GFR glomerular filtration rate