Table 2. Contraindications to Thrombolytic Therapy in Deep Vein Thrombolsis.

Absolute contraindications

Active internal bleeding or DIC

Recent neurovascular event (< 3 months)

CVA (including TIA), neurosurgery (intracranial, spinal), or intracranial trauma

Absolute contraindication to anticoagulation

Relative contraindications

Recent major event (< 7–10 days)

CPR, major surgery, cataract surgery, obstetrical delivery, organ biopsy, or major trauma

Neurological disorder

Intracranial lesion (including tumor) or seizure disorder

Uncontrolled hypertension: systolic BP > 180 mm Hg, diastolic BP > 110 mm Hg

Recent major gastrointestinal bleeding or internal eye surgery (< 3 months)

Serious allergic or other reaction to thrombolytic agent, anticoagulant, or contrast media (not controlled by steroid/antihistamine pretreatment)

Severe thrombocytopenia

Known right-to-left cardiac or pulmonary shunt or left heart thrombus

Severe dyspnea or severe acute medical illness precluding safe procedure performance

Suspicion for infected venous thrombus

Renal failure (estimated GFR < 60 mL/min)

Pregnancy or lactation

Severe hepatic dysfunction

Bacterial endocarditis

Diabetic hemorrhagic retinopathy

This table was modified from the article by Vedantham et al. J Vasc Interv Radiol 2014;25:1317-1325, with permission of Elsevier Inc. [12].

BP = blood pressure, CPR = cardiopulmonary resuscitation, CVA = cerebrovascular accident, DIC = disseminated intravascular coagulation, GFR = glomerular filtration rate, TIA = transient ischemic attack