Table 4. Diagnostic Accuracy of 2D SWE Score in Predicting Histological Fibrosis Stages in All Patients, Patients with BA and Patients without BA.
| AUROCs (95% CI) | Cut-Off Value | Sensitivity | Specificity | NPV | PPV | Accuracy | |
|---|---|---|---|---|---|---|---|
| All patients (n = 216) | |||||||
| ≥ F1 | 0.941 (0.901–0.968) | 9.1 | 85.2 (79.4–89.9) | 95.0 (75.1–99.9) | 32.8 (19/58) | 99.4 (157/158) | 81.5 |
| ≥ F2 | 0.869 (0.817–0.911) | 11.6 | 78.2 (70.2–84.9) | 83.1 (73.3–90.5) | 70.4 (69/98) | 88.1 (104/118) | 80.1 |
| ≥ F3 | 0.941 (0.901–0.969) | 13.0 | 93.4 (85.3–97.8) | 85.0 (78.0–90.5) | 96.0 (119/124) | 77.2 (71/92) | 88.0 |
| ≥ F4 | 0.889 (0.736–0.916) | 15.7 | 78.6 (59.0–91.7) | 81.9 (75.7–87.1) | 96.3 (154/160) | 39.3 (22/56) | 81.5 |
| BA patients (n = 168) | |||||||
| ≥ F1 | 0.935 (0.887–0.967) | 9.1 | 90.1 (84.4–94.2) | 85.7 (42.1–99.6) | 27.3 (6/22) | 99.3 (145/146) | 89.9 |
| ≥ F2 | 0.836 (0.772–0.889) | 12.1 | 77.1 (68.5–84.3) | 82.0 (68.6–91.4) | 60.3 (41/68) | 91.0 (91/100) | 78.6 |
| ≥ F3 | 0.918 (0.866–0.955) | 13.5 | 89.9 (80.2–95.8) | 83.8 (75.1–90.5) | 92.1 (82/89) | 78.5 (62/79) | 85.7 |
| ≥ F4 | 0.855 (0.793–0.905) | 15.7 | 75.0 (53.3–90.2) | 77.8 (70.1–84.) | 94.9 (112/118) | 36.0 (18/50) | 77.4 |
| Non-BA patients (n = 48) | |||||||
| ≥ F1 | 0.870 (0.742–0.950) | 9.0 | 62.9 (44.9–78.5) | 100.0 (75.3–100.0) | 50.0 (13/26) | 100.0 (22/22) | 72.9 |
| ≥ F2 | 0.896 (0.774–0.965) | 9.0 | 93.3 (68.1–99.8) | 75.8 (57.7–88.9) | 96.2 (25/26) | 63.6 (14/22) | 81.2 |
| ≥ F3 | 1.0 (0.926–1.0) | 14.3 | 100.0 (59.0–100.0) | 100.0 (91.4–100.0) | 100.0 (41/41) | 100.0 (7/7) | 100.0 |
| ≥ F4 | 0.977 (0.886–0.999) | 14.5 | 100.0 (39.8–100.0) | 95.5 (84.5–99.4) | 100.0 (42/42) | 66.7 (4/6) | 95.8 |
AUROCs = area under receiver operating characteristic curves, BA = biliary atresia, CI = confidence interval, NPV = negative predictive value, PPV = positive predictive value, SWE = shear wave elastography, 2D = two-dimensional