Fig. 11.

Clinical perspective—Virtual imaging trials. Population of whole-body phantoms, left. Anatomically variable human heart models are created by morphing the template Living Heart Model geometry to fit segmented patient-specific computer tomography data, top right. The new personalized models are placed within selected phantoms. To simulate coronary artery disease, plaques of any given size or material definition can be placed within the coronary vessels. The phantoms models can then be imaged with our computer tomography simulation framework to produce imaging data under various devices or parameters, bottom right. Simulated computer tomography data with and without cardiac motion during mid-diastole illustrate the plaque