Fig. 1.

Overview of the methods. Each tibia was dissected (A) and the extremities were embedded in resin (B). A microCT scan was acquired for each tibia (C). The microCT scans were used to generate specimen-specific microFE models (E). Subsequently, each tibia was tested in compression (D). From the experimental curves, stiffness (S) and failure load (Fu) were measured. Mechanical properties were estimated from the models and compared to the experimental measurements. Regression analysis was used to evaluate the ability of each model to predict the experimental mechanical properties