Table 3.

Regression parameters between experimental and predicted mechanical properties

	Slope	Intercept	R2	RMSE	P value	Error
Hexa-homo (E = 14.8GPa)
S (N/mm)	1.02*	9**	0.65	38	< 0.001	14% ± 8%
S_norm (N/mm/mg)	1.20*	− 3**	0.80	4.58	< 0.001	14% ± 8%
Fu (N)	0.64	16	0.48	4.69	0.001	9% ± 6%
Fu_norm (N/mg)	1.07*	0**	0.81	0.56	< 0.001	9% ± 6%
Hexa-homo (TMD)
S (N/mm)	1.08*	15**	0.56	42	< 0.001	16% ± 11%
S_norm (N/mm/mg)	1.51	− 9**	0.80	4.58	< 0.001	16% ± 11%
Fu [N]	0.57	21	0.35	5.26	0.006	12% ± 6%
Fu_norm (N/mg)	1.46	− 2	0.79	0.58	< 0.001	12% ± 6%
Tetra-homo (E = 14.8GPa)
S (N/mm)	0.95*	16**	0.62	39	< 0.001	13% ± 11%
S_norm (N/mm/mg)	1.11*	− 2**	0.78	4.81	< 0.001	13% ± 11%
Fu (N)	0.61	18	0.43	4.94	0.002	10% ± 7%
Fu_norm (N/mg)	1.09*	0**	0.77	0.61	< 0.001	10% ± 7%
Tetra-homo (TMD)
S (N/mm)	1.01*	20**	0.54	43	< 0.001	15% ± 12%
S_norm (N/mm/mg)	1.40	− 8**	0.78	4.84	< 0.001	15% ± 12%
Fu (N)	0.55	21	0.33	5.34	0.008	11% ± 7%
Fu_norm (N/mg)	1.36	− 2**	0.79	0.59	< 0.001	11% ± 7%
Hexa-hete
S (N/mm)	0.99*	37**	0.49	45	0.001	17% ± 12%
S_norm (N/mm/mg)	1.49	-8**	0.75	5.14	< 0.001	17% ± 12%
Fu (N)	0.55	23	0.32	5.37	0.009	12% ± 7%
Fu_norm (N/mg)	1.41	− 2**	0.76	0.63	< 0.001	12% ± 7%
Tetra-hete
S (N/mm)	1.03*	24**	0.53	44	< 0.001	16% ± 12%
S_norm (N/mm/mg)	1.49	− 8**	0.78	4.77	< 0.001	16% ± 12%
Fu (N)	0.38	30	0.21	5.80	0.042	15% ± 10%
Fu_norm (N/mg)	1.19*	0**	0.55	0.86	< 0.001	15% ± 10%

S stiffness (N/mm), S_norm normalized stiffness (N/mm/mg), Fu  failure load (N), Fu_norm normalized failure load (N/mg), Hexa hexahedral mesh, Tetra tetrahedral mesh, Homo homogeneous material properties (either E = 14.8 GPa or sample-specific E based on the average tissue mineral density, TMD), Hete heterogeneous material properties based on TMD

*Indicates that the slope was not significantly different from 1 (p value > 0.05). **Indicates that the intercept was not significantly different from 0 (p value > 0.05)