Table 1.
Patient characteristics at baseline and functional improvement over time
|
ID |
Age | Sex | Medical History | Lesioned hemisphere/ dominance | Thombolysis/ Thrombectomy (TICI) | LVO | Lesion volume (ml) | Exam acute C/I | NIHSS |
UEFM |
MRS |
BI |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acute | LSA | Acute | LSA | Acute | LSA | Acute | LSA | |||||||||
| 1 | 78 | Female | HT, HC | Left/d | No/no | None | 33.6 | 7/7 | 10 | 3 | 8 | 31 | 4 | 3 | 35 | 80 |
| 2 | 63 | Male | HT, DM, HC | Left/d | No/no | M1 | 55.8 | 3/3 | 13 | 1 | 5 | 36 | 4 | 1 | 40 | 100 |
| 3 | 73 | Female | HT, AF, Hthy | Left/d | Yes/yes (2B) | M1 | 14.4 | 5/5 | 9 | 3 | 48 | 65 | 4 | 3 | 20 | 100 |
| 4 | 73 | Female | – | Right/n | Yes/yes (2A) | M1 | 27.6 | 5/5 | 5 | 2 | 49 | 62 | 4 | 1 | 25 | 80 |
| 5 | 79 | Female | MG | Right/n | Yes/yes (2B) | M2/A1 | 120.4 | 5/6 | 8 | 2* | 15 | 51* | 5 | 4 | 10 | 85* |
| 6 | 89 | Female | HT | Right/n | Yes/no | none | 2.6 | 4/4 | 7 | 3 | 5 | 39 | 5 | 3 | 40 | 55 |
| 7 | 71 | Female | HT, AF | Right/n | Yes/yes (2A) | ACI/M1/A1 | 38.4 | 8/8 | 9 | – | 4 | 47* | 5 | 3* | 10 | 70* |
| 8 | 76 | Male | – | Right/n | Yes/yes (3) | M1/A2 | 101.0 | 5/6 | 11 | – | 4 | – | 5 | 3† | 10 | – |
| 9 | 78 | Male | HT, DM, AF | Right/n | Yes/yes (3) | M2 | 178.1 | 4/4 | 17 | 3 | 5 | 15 | 5 | 4 | 10 | 65 |
| 10 | 85 | Female | HT, DM, AF, BAVR, HC | Right/n | No/yes (2B) | M1 | 33.5 | 5/5 | 15 | 14 | 2 | 4 | 5 | 5 | 0 | 0 |
| 11 | 78 | Male | HT, AF | Left/d | No/no | M1 | 58.1 | 10/15 | 17 | – | 3 | – | 5 | 5*,† | 10 | 15*,† |
| 12 | 74 | Male | HT, DM, HC, AF | Left/d | Yes/yes (2B) | M1 | 303.3 | 10/10 | 24 | – | 5 | 4* | 5 | 5 | 5 | 5 |
| 13 | 69 | Male | HT, HUR | Left/d | Yes/yes (2A) | M1 | 98.4 | 7/7 | 18 | – | 0 | – | 5 | – | 0 | – |
| 14 | 77 | Female | HT, Asthma, AF | Right/n | Yes/no | M1 | 286.7 | 7/7 | 11 | 10* | 4 | 4* | 4 | 4* | 20 | 45* |
| 15 | 67 | Female | OS | Right/n | Yes/no | None | 7.4 | 8/7 | 11 | 7 | 6 | 5* | 4 | 3 | 30 | 95 |
| 16 | 58 | Female | HT, HC | Left/d | No/no | ACI/M1 | 58.4 | 13/13 | 23 | – | 0 | – | 5 | – | 5 | – |
| 17 | 80 | Female | HT, AF | Left/d | No/no | M1 | 20.5 | 12/12 | 11 | 15* | – | 4* | 5 | 4* | 0 | 30* |
| 18 | 83 | Female | HT, AF, CAD | Left/d | Yes/yes (3) | Carotis-T | 21.6 | 9/9 | 10 | – | 6 | – | 5 | – | 20 | – |
| 19 | 80 | Male | HT, DM, HC, AF, Obesity | Right/n | Yes/yes (0) | M1 | 108.4 | 7/7 | 16 | – | 6 | – | 5 | 6† | 10 | – |
| Patients | 73.8 (5.8) | 7 male | 10 right/9 d | 13 thrombolysis/ 11 thrombectomy | Modal: M1 | 82.5 (87.6) | Mode: 5/7 | 12.89 (5.17) | 5.7 (5.0) | 9.7 (14.5) | 30.3 (23.3) | 4.7 (0.5) | 3.6 (1.4) | 15.8 (13.0) | 58.9 (34.8) | |
| Controls | 75.3 (7.5) | 7 male | – | – | – | – | – | – | – | – | – | – | – | – | ||
Baseline characteristics of all patients individually and averaged per group, for patients and controls. Modal values or mean values and standard deviation in brackets are given. Medical history: AF, atrial fibrillation; BAVR, biological aortic valve replacement; CAD, coronary artery disease; DM, diabetes mellitus; HC, hypercholesterinaemia; HT, hypertension; HThy, hyperthyreosis; HUR, hyperuricaemia; MG, monoclonal gammopathy; OS, osteoporosis. Hemispherical dominance: d = dominant hemisphere, n = non-dominant hemisphere was affected by the lesion, TICI: thrombolysis in cerebral infarction grading system, partial perfusion of the treated vessel is reached in grade 2B (mode). LVO, large vessel occlusion, M1/M2/A1/ACI indicate the cerebral vessels occluded. Exam time point of clinical examination (C) and imaging (I) in days after stroke. Recovery and initial scoring of four major scales: NIHSS, National Institute of Health Stroke Scale; UEFM, Upper Extremity Fugl Meyer Assessment; MRS, modified Rankin Scale; BI, Barthel-Index. Time point of data collection in the acute (day 4–14) or late sub-acute stage (LSA), either 3 or 6 months (depicted by *) after stroke. †Follow-up values collected via phone.