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. 2021 May 26;11:11005. doi: 10.1038/s41598-021-90565-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Forelimb grip test during the aging process in female Fgf2KO mice. The same mice were subjected to the grip strength test at 3, 5 and 15 months of age. Measurements were performed 3 times per day for 3 days, and the data were averaged as an individual value. Time course of muscle grip force analyzed by the Two-way repeated measure ANOVA, along with Tukey’s multiple comparison test showed that no grip strength differences were observed between 3 and 5 m WT mice, however there was a significant reduction between 3 m WT and 15 m WT as well as 5 m WT and 15 m WT. There were no significant differences between 3 and 5 m WT and 3 m and 5 m Fgf2KO mice. There were no significant differences between 3 and 5 m Fgf2KO mice, however there was a significant reduction between 3 m Fgf2KO and 15 m Fgf2KO as well as 5 m Fgf2KO and 15 m Fgf2KO. There was a further significant reduction of grip strength between 15 m WT and 15 m KO. n = 3 mice/group. *Compared to corresponding WT p < 0.05, ^#compared to corresponding 5 m p < 0.05, ^@compared to corresponding 3 m p < 0.05.