Table 4.

Primary outcomes—adverse cardiovascular outcomes

Adverse cardiovascular outcomes	Definitions and codes
Ischaemic heart disease	At least one hospital diagnosis: ICD-10-CA codes: I20–I25) OR At least two ambulatory visit diagnoses: ICD-9-CM codes: 410–414 OR At least one ambulatory visit diagnosis: ICD-9-CM codes: 410–414 AND at least two prescriptions: vasodilators (Anatomical Therapeutic Chemical (ATC) codes: C01DA02, C01DA05, C01DA08, C01DA14), other cardiac drugs (ATC codes: C01EB09), beta blocking agents (ATC codes: C07AA02, C07AA03, C07AA05, C07AA06, C07AA12, C07AB02, C07AB03, C07AB04, C07AB07, C07AG01, C07BA05, C07BA06, C07BA12, C07CA03, C07CB03), calcium channel blockers (ATC codes: C08CA01, C08CA02, C08CA04, C08CA05, C08CA06, C08DA01, C08DB01), ACE inhibitors (ACEI; ATC codes: C09AA01, C09AA02, C09AA03, C09AA04, C09AA05, C09AA06, C09AA07, C09AA08, C09AA09, C09AA10, C09BA02, C09BA03, C09BA04, C09BA06, C09BA08), angiotensin II antagonists (ATC codes: C09CA01, C09CA02, C09CA03, C09CA04, C09CA06, C09CA07, C09DA01, C09DA02, C09DA03, C09DA04, C09DA06, C09DA07) in 3 years
Acute myocardial infarction	ICD-10-CA codes: I21.0–I21.4, I21.9–I22.1, I22.8, I22.9, I51.3
Ischaemic/haemorrhagic stroke	ICD-9-CM codes: 430–438 or ICD-10-CA codes: I60–I69
Transient ischaemic attack	ICD-10-CA codes: G45.0–45.3, G45.9
Peripheral artery disease	ICD-9-CM codes: 440, 443 or ICD-1-CA codes: I70, I73, I79
Congestive heart failure	ICD-9-CM codes: 428 or ICD-10-CA code: I50
Cardiovascular-related interventions (such as CABG and PCI)	Example: ICD-9-CM codes: 36,10–36, 14 or Canadian Classification of Health Interventions (CCI) codes: 3610–3616, 3619
Hypertension*	At least one hospital diagnosis: ICD10-CA codes: I10–I15 OR At least two ambulatory visit diagnoses: ICD-9-CM codes: 401–405 OR At least two prescriptions: antihypertensives (ATC codes: C02AB01, C02DC01), diuretics (ATC codes: C03BA11, C03DB02), beta blocking agents (ATC codes: C07AA12, C07AB03, C07CA03), calcium channel blocker (ATC codes: C08DA01), ACEI (ATC codes: C09AA05, C09BA02), angiotensin II antagonists (ATC codes: C09CA01, C09DA01)
Prescription of cardiac medications	Example: prescriptions such as antihypertensives (ATC codes: C02AB01, C02DC01), diuretics (ATC codes: C03BA11, C03DB02), beta blocking agents (ATC codes: C07AA12, C07AB03, C07CA03), calcium channel blocker (ATC codes: C08DA01), ACEI (ATC codes: C09AA05, C09BA02), angiotensin II antagonists (ATC codes: C09CA01, C09DA01)

*This outcome will only be used for those participants with no prior diagnosis of hypertension.

CABG, coronary artery bypass graft; ICD-10-CA, International Classification of Diseases, 10th revision, Canada; ICD-9-CM, International Classification of Diseases, 9th revision, clinical modification; PCI, percutaneous coronary intervention.