Table 2.
Number needed to treat to harm for aortic pathologies.
| Aortic pathology (assumed rate ratio) |
Assumed baseline incidence of aortic pathology (number of events per 100,000 patient years) Note: baseline incidence may vary across geography, gender, age, and other clinical characteristics. A range of estimates regarding baseline incidence are provided below for ease of reference to clinicians, who should tailor their decisions accordingly |
Number needed to harm (NNH) (95% CI) |
|---|---|---|
|
Aortic dissection or aneurysm rupture (Pooled rate ratio: 2.38 [95% CI 1.71 to 3.32]) |
3 | 24,155 (95% CI: 14,430 to 46,948) |
| 5 | 14,493 (95% CI: 8658 to 28,169) | |
| 10 | 7246 (95% CI: 4329 to 14,085) | |
| 15 | 4831 (95% CI: 2886 to 9390) | |
| 25 | 2899 (95% CI: 1732 to 5634) | |
| 50 | 1449 (95% CI: 866 to 2817) | |
| 75 | 966 (95% CI: 577 to 1878) | |
| 100 | 725 (95% CI: 433 to 1408) | |
| 125 | 580 (95% CI: 346 to 1127) | |
| 150 | 483 (95% CI: 289 to 939) | |
|
Aortic aneurysm (Pooled rate ratio: 1.98 [95% CI 1.59 to 2.48]) |
5 | 20,408 (95% CI: 13,514 to 33,898) |
| 25 | 4082 (95% CI: 2703 to 6780) | |
| 50 | 2041 (95% CI: 1351 to 3390) | |
| 75 | 1361 (95% CI: 901 to 2260) | |
| 100 | 1020 (95% CI: 676 to 1695) | |
| 125 | 816 (95% CI: 541 to 1356) | |
| 150 | 680 (95% CI: 450 to 1130) | |
| 250 | 408 (95% CI: 270 to 678) | |
| 300 | 340 (95% CI: 225 to 565) |