Table 1.
Baseline cohort demographics for patients without a prior psychiatric (F20–F48) diagnosis.
| CCB | Diuretic | CCB | ACEI | CCB | ARB | CCB | BB | |
|---|---|---|---|---|---|---|---|---|
| Number | 192,161 | 192,161 | 270,326 | 270,326 | 192,164 | 192,164 | 206,703 | 206,703 |
| Age at index (years) | 59.9 (14.7) | 59.9 (14.6) | 60.5 (14.4) | 60.4 (13.8) | 60.0 (13.6) | 60.3 (12.8) | 59.6 (14.3) | 59.8 (14.4) |
| Sex (M:F %) | 52: 48 | 52: 48 | 48: 52 | 48: 52 | 47: 53 | 46: 54 | 48: 52 | 48: 52 |
| Racea (% W,B, O) | 64, 21, 15 | 64, 20, 16 | 67, 18, 15 | 67, 19, 14 | 70, 12, 18 | 70, 11, 19 | 66, 21, 13 | 66, 21, 13 |
| Blood pressure | 137/79 | 136/79 | 136/78 | 135/79 | 133/77 | 133/78 | 138/80b | 134/78b |
| Prior diuretic (%) | – | – | 36 | 37 | 36 | 47 | 34 | 34 |
| Prior ACEI (%) | 29 | 36 | – | – | 42 | 18 | 31 | 29 |
| Prior ARB (%) | 14 | 19 | 32 | 2 | – | – | 19 | 12 |
| Prior BB (%) | 30 | 33 | 35 | 28 | 38 | 31 | – | – |
| Prior other AHT (%) | 10 | 7 | 11 | 6 | 12 | 7 | 8 | 7 |
| Prior antidepressant (%) | 15 | 14 | 16 | 14 | 18 | 17 | 15 | 17 |
| Prior anxiolytic (%) | 20 | 19 | 23 | 17 | 25 | 20 | 18 | 23 |
| Prior antipsychotic (%) | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 |
Each cohort pair is propensity score-matched for age, sex, race, and blood pressure (most recent recorded value).
aW: white, B: black or African American, O: other or not known.
All variables matched except: bSD = 0.19 systolic, 0.16 diastolic.