Table 2.
Diagnostic outcomes for patients without a prior psychiatric (F20–F48) diagnosis.
| Disorder | ICD-10 codes | CCB vs diuretic | CCB vs ACEI | CCB vs ARB | CCB vs BB | ||||
|---|---|---|---|---|---|---|---|---|---|
| % in each cohort | Risk ratio (95% CI) | % in each cohort | Risk ratio (95% CI) | % in each cohort | Risk ratio (95% CI) | % in each cohort | Risk ratio (95% CI) | ||
| Psychotic disorder | F20–29 | 0.6, 0.6 | 1.02 (0.94–1.11) | 0.6, 0.6 | 1.04 (0.98–1.12) | 0.73, 0.33 | 2.23 (2.03–2.45) | 0.52, 0.76 | 0.69 (0.64–0.75) |
| Affective disorder | F30–39 | 8.3, 8.7 | 0.95 (0.93–0.97) | 9.1, 8.7 | 1.05 (1.04–1.07) | 9.8, 7.7 | 1.27 (1.24–1.29) | 8.6, 9.7 | 0.88 (0.86–0.90) |
| Depression | F32,33 | 7.4, 7.8 | 0.95 (0.93–0.97) | 8.2, 7.7 | 1.06 (1.04–1.08) | 8.8, 7.0 | 1.26 (1.23–1.29) | 7.6, 8.6 | 0.88 (0.86–0.90) |
| Anxiety disorder | F40–48 | 9.1, 8.6 | 1.06 (1.04–1.08) | 9.7, 8.6 | 1.13 (1.11–1.15) | 10, 8.6 | 1.19 (1.17–1.22) | 9.1, 10 | 0.89 (0.87–0.91) |
| Sleep disorder | F51, G47 | 12, 15 | 0.79 (0.78–0.81) | 15, 13 | 1.18 (1.16–1.19) | 14, 14 | 1.01 (0.99–1.02) | 13, 14 | 0.97 (0.95–0.98) |
| Substance use disorder | F10–19 | 9.6, 9.2 | 1.04 (1.02–1.06) | 8.7, 9.1 | 0.95 (0.94–0.97) | 11, 5.6 | 1.94 (1.90–1.99) | 8.7, 10 | 0.86 (0.84–0.87) |
| Negative control outcomesa | – | 0.88 (0.82–0.93) | – | 0.96 (0.90–1.02) | – | 1.00 (0.93–1.08) | – | 1.11 (1.02–1.19) | |
aMean of 12 negative control outcomes (see Supplementary Table 1).
Bold values indicate statistical significance.