Table 4.
Diagnostic outcomes for patients with a prior psychiatric (F20–F48) diagnosis.
| Disorder | ICD-10 codes | CCB vs Diuretic | CCB vs ACEI | CCB vs ARB | CCB vs BB | ||||
|---|---|---|---|---|---|---|---|---|---|
| % in each cohort | Risk ratio (95% CI) | % in each cohort | Risk ratio (95% CI) | % in each cohort | Risk ratio (95% CI) | % in each cohort | Risk ratio (95% CI) | ||
| Psychotic disorder | F20–29 | 4.1, 3.8 | 1.07 (0.99–1.15) | 3.7, 4.0 | 0.91 (0.86–0.97) | 3.8, 2.1 | 1.82 (1.67–1.98) | 3.6, 4.7 | 0.76 (0.71–0.81) |
| Schizophrenia | F20 | 2.0, 1.7 | 1.15 (1.03–1.28) | 1.6, 1.9 | 0.82 (0.74–0.89) | 1.6, 0.8 | 1.95 (1.70–2.24) | 1.7, 2.2 | 0.77 (0.70–0.86) |
| Affective disorder | F30–39 | 46, 46 | 0.99 (0.97–1.01) | 46, 46 | 1.00 (0.99–1.01) | 49, 45 | 1.08 (1.06–1.09) | 46, 46 | 0.99 (0.98–1.01) |
| Bipolar disorder | F30,31 | 6.1, 5.4 | 1.13 (1.07–1.21) | 5.4, 5.5 | 0.99 (0.94–1.05) | 6.2, 3.7 | 1.67 (1.56–1.78) | 5.2, 6.1 | 0.86 (0.82–0.91) |
| Depression | F32,33 | 39, 40 | 0.98 (0.96–0.99) | 41, 41 | 1.00 (0.99–1.02) | 43, 41 | 1.06 (1.04–1.08) | 40, 41 | 0.99 (0.97–1.01) |
| Anxiety disorder | F40–48 | 42, 41 | 1.04 (1.02–1.05) | 43, 41 | 1.05 (1.04–1.07) | 44, 42 | 1.04 (1.03–1.06) | 41, 44 | 0.94 (0.92–0.95) |
| Sleep disorder | F51, G47 | 26, 29 | 0.89 (0.87–0.92) | 31, 27 | 1.16 (1.13–1.18) | 31, 31 | 1.00 (0.98–1.03) | 28, 29 | 0.97 (0.95–1.00) |
| Substance use disorder | F10–19 | 21, 20 | 1.08 (1.05–1.11) | 19, 20 | 0.96 (0.93–0.98) | 22, 14 | 1.57 (1.52–1.62) | 19, 20 | 0.97 (0.95–1.00) |
| Negative control outcomesa | – | 0.88 (0.82–0.94) | – | 1.07 (1.00-1.14) | – | 0.99 (0.89–1.10) | – | 1.00 (0.92–1.08) | |
aMean of 12 negative control outcomes (see Supplementary Table 1).
Bold values indicate statistical significance.