Table 5.

Comparison of ARBs with ACEIs.

		ARB vs ACEI (prior psychiatric diagnosis)		ARB vs ACEI (no prior psychiatric diagnosis)
Baseline characteristics		ARB	ACEI	ARB	ACEI
Number		49,314	49,314	322,814	322,814
Age at index (years)		60.6 (12.8)	60.6 (12.8)	62.3 (12.4)	62.4 (12.6)
Sex (M:F %)		30:70	30:70	46:54	46:54
Race (% W, B, O)a		76, 15, 9	77, 15, 8	65, 16, 19	66, 16, 18
Blood pressure		135/78	135/78	137/78	137/78
Outcomes	ICD-10 codes	% in each cohort (ARB, ACEI)	Risk ratio (95% CI)	% in each cohort (ARB, ACEI)	Risk ratio (95% CI)
Psychotic disorder	F20-29	2.5, 4.0	0.61 (0.57–0.66)	0.4, 0.7	0.57 (0.54–0.61)
Schizophrenia	F20	0.9, 1.8	0.52 (0.46–0.58)	0.08, 0.2	0.39 (0.33–0.45)
Affective disorder	F30-39	45, 48	0.94 (0.93–0.95)	8.7, 9.4	0.92 (0.91–0.94)
Bipolar disorder	F30,31	4.0, 5.5	0.73 (0.69–0.77)	0.4, 0.6	0.68 (0.63–0.73)
Major depression	F32,33	40, 43	0.94 (0.93–0.96)	7.9, 8.4	0.93 (0.92–0.95)
Anxiety disorder	F40-48	44, 42	1.03 (1.02–1.05)	9.2, 8.7	1.05 (1.03–1.06)
Sleep disorder	F51, G47	32,29	1.13 (1.11–1.15)	16, 13	1.22 (1.21–1.24)
Substance use disorder	F10-19	14,21	0.66 (0.64–0.68)	5.7, 9.5	0.60 (0.59–0.61)

Cohorts propensity score-matched for age, sex, race, and blood pressure (most recent recorded value).

^aW: white, B: black or African American, O: other or unknown.

Bold values indicate statistical significance.