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. 2021 May 26;12:3172. doi: 10.1038/s41467-021-23541-x

Fig. 2. Importance of the linker regions in the formation of the Sema3A/PlexinA4/Nrp1 complex.

Fig. 2

a Roles of the linkers in connecting various parts of the proteins in the tripartite complex on the cell surface. The crystal structure of the MAM domain of Nrp1 (PDB ID: 5l73) is docked between the a2b1b2 module and the plasma membrane. Thick lines represent the linker regions. The arrows in the right panel (top view) indicate that the MAM-linker region may use two alternative paths (through the center or outside of the PlexinA4 ring) to connect to the TM region of Nrp1. b Sequence alignment of the b2-MAM and MAM-TM linkers from mouse Nrp1 and Nrp2. c Sequence alignment of the tail regions of mouse class 3 semaphorins. Putative furin-cleavage sites are highlighted.