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. 2021 May 26;12:3172. doi: 10.1038/s41467-021-23541-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overview of the PlexinA4-Sema/Nrp1-a1 interface. For clarity, only one Nrp1-a1 domain and one PlexinA4 molecule from the 2:2:2 complex are shown. One complex of PlexinA2/Nrp1-a1 from PDB ID 4gza is superimposed for comparison. b Detailed view of the PlexinA4-Sema/Nrp1-a1 interface. c Sequence alignment of the loop region which in mouse PlexinA4 contains Lys343 that is important for interacting with Nrp1-a1.