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. 2021 May 27;12(6):550. doi: 10.1038/s41419-021-03797-3

Fig. 3. Knockdown of SEC61G suppresses breast cancer cell proliferation, migration, invasion, and promotes breast cancer cell apoptosis in vitro.

Fig. 3

A MCF-7 or MDA-MB-231 cells were left untreated (Blank), or transfected with negative control (NC) or siRNAs targeting SEC61G. The relative protein expression of SEC61G in MCF-7 or MDA-MB-231 cells was analyzed by western blot. B–D MCF-7 or MDA-MB-231 cells were left untreated or transfected with NC or si-SEC61G-3. B Cell proliferation was analyzed by CCK-8 assay at the indicated time points. C DNA synthesis was analyzed by the EDU incorporation assay. D Cell growth was assessed by colony formation assay. E Cell invasion was assessed by transwell assay. F Cell apoptosis was analyzed by Annexin V/7-AAD double staining. *P < 0.05, **P < 0.01, ***P < 0.001.