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. 2021 May 26;11:11004. doi: 10.1038/s41598-021-90092-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representation of cardiac remodeling with the aid of gene expression of relevant markers such as elastin 7 days (A) and 30 days (E) after permanent ligation. Expression of collagen III 7 days (B) and 30 days (F) after permanent ligation. In (B) collagen III-expression was significantly increased in wild-type mice compared to CX3CR1-KO mice, which shows early remodeling in wild type mice, but no statistically relevant difference in functional outcome, (C) represents increased monocyte-expression (F4/80) in CCR2-KO-mice compared to CX3CR1-KO mice and to MCP-1-KO mice 7 days, (G) shows monocyte-expression 30 days after MI. In (D) an increased TNF-alpha gene expression was seen in CCR2-KO mice compared to CX3CR1-KO mice, (H) represents TNF-alpha gene expression 30 days after MI.