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. 2021 May 26;11:11001. doi: 10.1038/s41598-021-90215-5

Table 1.

Demographic characteristics of patients treated with and without nCRT.

Before propensity score matching After propensity score matching
Open
(n = 147)
MIS
(n = 166)
p Open
(n = 118)
MIS
(n = 118)
p
Age (years, median ± (SD) 58 ± 12 57 ± 11 0.770 58 ± 12 58 ± 11 0.879
Sex, n (%) 0.552 0.893
Male 89 (60.5) 95 (57.2) 74 (62.7) 73 (61.9)
Female 58 (39.5) 71 (42.8) 44 (37.3) 45 (38.1)
BMI (kg/m2) 23.4 ± 3.2 23.3 ± 3.5 0.677 23.4 ± 2.8 23.3 ± 3.1 0.700
ASA score, n (%) 1.000 1.000
 < 3 146 (99.3) 165 (99.4) 117 (99.2) 117 (99.2)
 ≥ 3 1 (0.7) 1 (0.6) 1 (0.8) 1 (0.8)
Underlying, n (%) 68 (46.3) 77 (46.4) 0.982 59 (50.0) 50 (50.0) 1.000
HTN 49 (33.3) 53 (31.9) 0.791 42 (35.6) 41 (34.7) 0.892
DM 20 (13.6) 27 (16.3) 0.511 17 (14.4) 20 (16.9) 0.591
IHD 7 (4.8) 4 (2.4) 0.259 6 (5.1) 4 (3.4) 0.518
COPD 10 (6.8) 4 (2.4) 0.061 9 (7.6) 4 (3.4) 0.154
Operative period  < 0.001  < 0.001
2000–2008 58 (39.5) 7 (4.2) 47 (39.8) 5 (4.2)
2009–2014 89 (60.5) 159 (95.8) 71 (60.2) 113 (95.8)
Preoperative CEA (ng/mL) 2.8 ± 5.7 2.9 ± 6.7 0.885 3.1 ± 5.9 2.8 ± 6.3 0.697
Preoperative CA19-9 (ng/mL) 13.4 ± 16.2 13.1 ± 16.0 0.881 12.2 ± 7.2 13.7 ± 17.1 0.361
Tumor distance from AV (cm) 3.2 ± 1.5 3.0 ± 1.4 0.272 2.8 ± 1.7 2.9 ± 1.5 0.528
Neoadjuvant CCRT, n (%) 71 (48.3) 42 (25.3)  < 0.001 42 (35.6) 42 (35.6) 1.000
Adjuvant treatment, n (%) 104 (70.7) 93 (56.0) 0.007 80 (67.8) 78 (66.1) 0.782

nCRT neoadjuvant chemoradiotherapy, MIS minimally invasive surgery, BMI body mass index, ASA American society of anesthesiologists, HTN hypertension, DM diabetes mellitus, IHD ischemic heart disease, COPD chronic obstructive pulmonary disease, CEA carcinoembryonic antigen, AV anal verge.