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. 2021 May 26;4:629. doi: 10.1038/s42003-021-02146-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a and b Top 20 genes whose expression in astrocytes (panel a) and microglia (panel b) were correlated with the expression of APOE at the single-cell level. The correlation measured by log(FC) was obtained by NEBULA in two snRNA-seq data sets^5,78 in the frontal cortex from the ROSMAP. c and d Top 10 KEGG pathways in which the genes most correlated with APOE in astrocytes (panel c) and microglia (panel d) were enriched. The size of the circles indicates how many genes were found in that pathway. The color indicates the p-value of the enrichment.