Table 2.
Concentrations of 26 compounds (ng/mL) in prenatal urine (not creatine adjusted) and blood samples, overall and by sex, n = 1,118.
| Components of the EDC mixture | Overall (n = 1,118) |
Boys (n = 584) |
Girls (n = 534) |
P-value* | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Matrix | Chemical Type | Parent compound (if applicable) |
Analyte | LOD/LOQa | % ≥ LOD | GM (GSD) | GM (GSD) | GM (GSD) | ||||
| Urine | Phthalates | DEP | MEP | 0.010 | 100 | 67.5 (2.9) | 69.1 (2.8) | 65.7 (3.1) | 0.432 | |||
| DBP | MBP | 0.100 | 100 | 67.4 (2.2) | 69.4 (2.2) | 65.4 (2.2) | 0.211 | |||||
| BBzP | MBzP | 0.040 | 100 | 15.6 (2.9) | 15.7 (2.8) | 15.5 (3.0) | 0.812 | |||||
| DEHP | ΣDEHPb | – | 63.8 (2.4) | 62.4 (2.3) | 65.4 (2.5) | 0.360 | ||||||
| DINP | ΣDINPc | – | 25.6 (3.0) | 25.3 (3.0) | 26.0 (3.0) | 0.688 | ||||||
| DiDP/DPHP | MHiDP | 0.031 | 100 | 1.23 (2.8) | 1.25 (2.7) | 1.20 (2.8) | 0.600 | |||||
| MCiNP | 0.031 | 99.9 | 0.66 (2.4) | 0.68 (2.4) | 0.65 (2.5) | 0.305 | ||||||
| Plasticizer | DiNCH | MOiNCH | 0.023 | 99.0 | 0.30 (4.0) | 0.31 (4.1) | 0.30 (4.0) | 0.887 | ||||
| TTP | DPP | 0.042 | 100 | 1.38 (2.6) | 1.44 (2.6) | 1.32 (2.5) | 0.115 | |||||
| Antibacterial | Triclosan | 0.100 | 92.4 | 1.34 (10.1) | 1.36 (10.5) | 1.31 (9.7) | 0.762 | |||||
| Bisphenols | BPA | 0.050 | 100 | 1.48 (2.4) | 1.51 (2.3) | 1.47 (2.4) | 0.636 | |||||
| BPF | 0.024 | 90.3 | 0.15 (5.2) | 0.16 (5.1) | 0.15 (5.3) | 0.535 | ||||||
| BPS | 0.009 | 97.5 | 0.07 (2.9) | 0.07 (2.8) | 0.06 (3.0) | 0.079 | ||||||
| PAH | 2OHPH | 0.003 | 100 | 0.20 (2.3) | 0.20 (2.3) | 0.21 (2.3) | 0.582 | |||||
| Pesticide | Chlorpyrifos | TCP | 0.035 | 100 | 1.30 (2.5) | 1.30 (2.5) | 1.29 (2.6) | 0.880 | ||||
| Pyrethroids | 3-PBA | 0.017 | 99.0 | 0.16 (2.8) | 0.16 (2.7) | 0.16 (2.8) | 0.964 | |||||
| Serum | PFAS | PFOA | 0.020 | 100 | 1.63 (1.7) | 1.65 (1.7) | 1.61 (1.8) | 0.451 | ||||
| PFOS | 0.060 | 100 | 5.49 (1.7) | 5.56 (1.7) | 5.42 (1.7) | 0.406 | ||||||
| PFNA | 0.010 | 100 | 0.55 (1.7) | 0.54 (1.7) | 0.55 (1.7) | 0.769 | ||||||
| PFDA | 0.020 | 100 | 0.26 (1.6) | 0.26 (1.6) | 0.26 (1.6) | 0.897 | ||||||
| PFUnDA | 0.020 | 99.7 | 0.22 (1.9) | 0.22 (1.9) | 0.22 (1.8) | 0.751 | ||||||
| PFHxS | 0.030 | 100 | 1.31 (1.8) | 1.32 (1.8) | 1.29 (1.8) | 0.530 | ||||||
| Plasma | Organo-chlorine pesticide | HCB | 0.005 | 100 | 0.05 (1.4) | 0.05 (1.4) | 0.04 (1.4) | 0.347 | ||||
| Trans-Nonachlor | 0.005 | 77.5 | 0.01 (1.8) | 0.01 (1.8) | 0.01 (1.8) | 0.989 | ||||||
| DDT | ΣDDT/DDEd | – | 0.20 (2.0) | 0.21 (2.0) | 0.20 (2.0) | 0.166 | ||||||
| PCB | ΣPCBe | – | 0.36 (1.7) | 0.37 (1.7) | 0.36 (1.7) | 0.500 | ||||||
Abbreviations: GM = Geometric mean, GSD = Geometric standard deviation, LOD = limit of detection, LOQ = limit of quantification.
Notes: Values < LOD retained the machine read value for urine and serum compounds, values < LOQ were substituted with LOQ/ 2 for plasma compounds. Further description of each analyte can be found in supplementary table S1.
a LOD reported for all urine and serum compounds, LOQ reported for plasma compounds.
b Molar sum of metabolites: mono-2-ethylhexyl, mono(2-ethyl-5-hydroxyhexyl), mono(2-ethyl-5-oxohexyl), and mono(2-ethyl-5-carboxypentyl) phthalates.
c Molar sum of metabolites: mono(hydroxyisononyl), mono(oxoisononyl), and mono(carboxyisooctyl) phthalates.
d Sum of DDT and its metabolite dichlorodiphenyldichloroethylene.
e Sum of PCB congeners 74, 99, 118, 138, 153, 156, 170, 180, 183, 187.
*P-value from Student t-test comparing metabolite concentrations on the log-scale by sex.