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. 2021 May 26;11:10997. doi: 10.1038/s41598-021-90517-8

Figure 1.

Figure 1

Clinical course of EAE. WT and MeCP2 mutant mice (MUT) were immunized with MOG and clinical signs were evaluated daily for 30 days. MUT-EAE mice showed an early EAE onset and developed more severe clinical signs in comparison to WT littermates. Data represent EAE clinical scores per group (mean ± SEM). Clinical scores per animal were calculated by adding tail and hind legs scores, and establishing a scale from 0 to 8, where 8 represents the highest EAE score per animal (i.e. 2 for the maximum tail score and 3 the maximum for each leg). Tail abnormalities were graded as: 0, no deficits, 1 partial loss of tail tone, 2 total tail paralysis. Each hind limb was graded as: 0, normal gait; 1, mild hind limb weakness; 2, dragged limp with abnormal gait; 3, complete hind limb paralysis with no residual movement. Two-factor ANOVA test with repeated measures was performed. *p < 0.05. WT-EAE n = 13; MUT-EAE n = 15.