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. 2021 May 26;11:10997. doi: 10.1038/s41598-021-90517-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Th2/Th1 ratios during acute EAE. Comparative ratios were calculated between the production of anti-inflammatory cytokines (IL-4, IL-10) and the pro-inflammatory cytokines (IFNγ and TNFα) from WT-EAE and MUT-EAE isolated splenocytes re-stimulated in vitro with MOG. The ratios between (a) IL-4/IFNγ and IL-4/ TNFα, (b) IL-10/IFNγ and IL-10/TNFα are displayed. The lower production of IL-10 from MUT-EAE + MOG splenocytes induced a decrease in the Th2/Th1 balance during the acute stage. All values are presented as media ± SEM. Mann–Whitney non-parametric test was performed. *p < 0.05. WT-EAE n = 4; MUT-EAE n = 5.