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. 2021 May 26;12(6):547. doi: 10.1038/s41419-021-03825-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Metastasis is a multistep process by which the primary BC cells undergo epithelial–mesenchymal transition (EMT) and dissociate from the initial site, intravasation, survival in the blood or lymphatic circulation, extravasation, and ultimately colonize distant sites. Exosomes from BC cells are crucial orchestrators to condition the pre-metastatic niche microenvironment in metastatic progression. Breast cancer BC, epithelial–mesenchymal transition EMT.