Fig. 2.
Effect of guanosine treatment in P70S6K phosphorylation, synapsin I, and PSD-95 imunocontent in the hippocampus and PFC of mice. Timeline of experimental protocols of administrations and behavioral tests (a). P70S6K (Thr389) phosphorylation in the hippocampus (b) and PFC (e) of mice. Immunocontent of synapsin I in the hippocampus (c) and PFC (f). Immunocontent of PSD-95 in the hippocampus (d) and PFC (g). Results are presented as percentual of control (considered 100%) and are expressed as mean + SEM (n = 6). * p < 0.05 and ** p < 0.01 guanosine-treated groups compared with the vehicle-treated group