Fig. 4.

Effect of guanosine or ketamine treatment in the NSF test and dendritic spine density and morphology in the hippocampal ventral DG. Timeline of experimental protocols of administrations and behavioral tests (a). Representative draw of the morphology of dendritic spines subtypes (b). Effect of a single administration of guanosine or ketamine in the latency to feed (c) and food consumption (d). Representative images of different dendritic segments in the ventral DG area for each experimental group (e). Percentage of each type of dendritic spine in each experimental group (f). Cumulative probability of total spine density (g), stubby- (h), thin- (i), mushroom- (j), and filopodia-shaped (k) dendritic spine in ventral DG. The results are expressed as absolute values and expressed as mean + SEM (n = 7–8). ** p < 0.01 compared with the vehicle-treated groups