Fig. 3.

A₁R and A_2AR modulation on ATP levels in striatal slices. Experimental design is describe in a. Effect of pre-incubation of A₁R antagonist, DPCPX (250 nM) (b) or A_2AR agonist, CGS21680 (CGS, 30 nM) (c) on 6-OHDA-induced ATP depletion. Slices were incubated with 6-OHDA (100 μM) and/or co-incubated with GUO (100 μM). Data are expressed as μmol ATP/μg of protein of each sample and represent means with SEM (n = 3). (*) when p < 0.05 compared with control or (#) compared to 6-OHDA group (one-way ANOVA followed by Tukey’s test)