Fig. 2.

Effect of adenosine receptor agonists in a glutamate-induced nociception model. Dose-response curve of (a) CHA—an adenosine A1 receptor agonist, (b) CGS21680—an adenosine A2a receptor agonist, (c) DPMA—an adenosine A2b receptor agonist, and (d) HEMADO—an adenosine A3 receptor agonist. CHA, CGS21680, DPMA, or HEMADO were administered by the intraplantar route 5 minutes before glutamate injection. Data are presented as mean±S.E.M. Statistical analysis was performed using one-way ANOVA followed by Student-Newman-Keuls post hoc test. s, seconds. *p<0.05, **p<0.01, and ***p<0.001 for comparisons of the effects of agonists and antagonists with those of vehicle. n = 2−3 total male and female mice