Fig. 3.

Effect of adenosine receptor antagonists in glutamate-induced nociception model. Dose-response curves of (a) DPCPX—an adenosine A1 receptor antagonist, (b) ZM241385—an adenosine A2a antagonist, and (c) alloxazine—an adenosine A2b receptor antagonist. DPCPX, ZM241385, or alloxazine were administered by the intraplantar route 5 minutes before glutamate injection. Data are presented as mean±S.E.M. Statistical analysis was performed using one-way ANOVA followed by Student-Newman-Keuls post hoc test. s, seconds. *p<0.05 for the comparisons of the effects of agonists and antagonists with those of vehicle. n = 3−5 total male and female mice