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. 2021 May 26;11:11051. doi: 10.1038/s41598-021-90438-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Oxaloacetate treatment from the symptomatic stage delays the onset of limb paralysis (neurological score of 3) of SOD1^G93A mice. (A) Oxaloacetate treatment from the presymptomatic stage (60 days old, red) did not alter the median age of onset of limb paralysis of SOD1^G93A mice compared to the control group of non-injected SOD1^G93A mice (black, p = 0.1793, log-rank test). (B) Oxaloacetate treatment from the symptomatic stage (110 days old, blue) significantly delayed the median age of onset for limb paralysis by seven days (p = 0.0157, log-rank test). The graphs show the Kaplan–Meier curve with n = 12 mice per group. These graphs contain mice that are identical to the mice in Fig. 1.