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. 2021 May 26;11:11051. doi: 10.1038/s41598-021-90438-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The lifespan of oxaloacetate-treated SOD1^G93A mice. (A) The median end-stage age of oxaloacetate treatment of SOD1^G93A mice from the presymptomatic stage (60 days old, red) was 158.5, which was the same as the control group of non-injected SOD1^G93A mice (black, p = 0.3717, log-rank test). (B) The median end-stage age of oxaloacetate treatment from the symptomatic stage (110 days old, blue) was 165 days. This median age was not statistically different from the control group (p = 0.051, log-rank test). The graphs show Kaplan–Meier curves with n = 12 mice per group. These graphs contain mice that are identical to the mice in Fig. 1.