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. 2021 May 26;11:10973. doi: 10.1038/s41598-021-90467-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reducing blood pressure (BP) effects induced by MA in SHRs. Differences in systolic blood pressure (SBP) (A) (H_{(Pre-acupuncture)} = 17.48, H_{(30 min)} = 25.68, H_{(60 min)} = 24.15, H_{(90 min)} = 17.48, Kruskal–Wallis Test) and (C) (F_(Day1) = 102.21, F_(Day2) = 101.11, F_(Day3) = 100.12, F_(Day4) = 103.36, F_(Day5) = 102.56, F_(Day6) = 108.47, F_(Day7) = 100.04, repeated measurement ANOVA) and diastolic blood pressure (DBP) (B) (H_{(Pre-acupuncture)} = 17.79, H_{(30 min)} = 25.32, H_{(60 min)} = 21.78, H_{(90 min)} = 18.12, Kruskal–Wallis Test) and (D) (F_(Day1) = 96.62, F_(Day2) = 97.40, F_(Day3) = 94.67, F_(Day4) = 95.72, F_(Day5) = 94.99, F_(Day6) = 98.54, F_(Day7) = 93.61, repeated measurement ANOVA) among WKY, SHR, MA and Sham-MA groups were detected at 30, 60 and 90 min after the first day of treatment, or every day of the 7-day treatment. *p < 0.05 versus the SHR group, ^#p < 0.05 versus the Sham-MA group.