Table 2. Effect of CzE on serum lipid profile levels in ApoE−/− mice.
| Samples | ALT (U/L) | AST (U/L) | TG (mg/dL) | TC (mg/dL) | Glucose (mg/dL) | HDL (mg/dL) | LDL (mg/dL) |
|---|---|---|---|---|---|---|---|
| ND | 56.7 ± 1.8 | 192.7 ± 21.8 | 75.3 ± 11.8 | 294.0 ± 14.5 | 50.0 ± 4.2 | 63.3 ± 2.4 | 231.1 ± 11.9 |
| HCD | 92.0 ± 15.6 | 264.0 ± 65.2 | 190.0 ± 15.3## | 874.0 ± 13.0### | 135.3 ± 12.7## | 180.0 ± 2.9### | 777.9 ± 12.7### |
| CzE | 74.0 ± 5.0 | 181.3 ± 5.9 | 108.7 ± 1.3** | 842.0 ± 23.2 | 80.0 ± 25.0 | 92.7 ± 3.5*** | 724.3 ± 27.9 |
| Simvastatin | 68.7 ± 11.2 | 177.0 ± 9.3 | 106.7 ± 11.9* | 701.3 ± 17.7** | 58.7 ± 3.3** | 82.0 ± 7.6*** | 562.0 ± 19.8** |
Data are presented as mean ± standard error of mean values (n = 3, each group). ApoE−/− mice treated with simvastatin were considered positive controls.
ND, normal diet; HCD, high-cholesterol diet; CzE, Curcuma zedoaria extract (HCD with CzE treatment group); Simvastatin, HCD with simvastatin treatment group; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TG, triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
*P < 0.05, **P < 0.01, ***P < 0.001 vs. HCD group; #P < 0.01, ##P < 0.001 vs. ND group.