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. 2021 Apr 5;12(5):782–790. doi: 10.1021/acsmedchemlett.1c00044

Table 2. Impact of Back Pocket Substituents on Potency.

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a

Each kinact and KI value was obtained from an average of two independent determinations (±SD). The method is described in the Supporting Information.

b

CD69 expression on mouse splenocytes was measured after stimulation with anti-IgM. nd = not determined.

c

Inhibition of anti-IgD-induced activation of B cells (B220+CD86+).

d

n = 1.