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. 2021 Apr 5;12(5):782–790. doi: 10.1021/acsmedchemlett.1c00044

Table 3. Lead Optimization through Modification of the Acrylamide Linker.

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a

Each kinact and KI value was obtained from an average of two independent determinations (±SD). The method is described in the Supporting Information.

b

CD69 expression on mouse splenocytes was measured after stimulation with anti-IgM. nd = not determined.

c

Inhibition of anti-IgD-induced activation of B cells (B220+CD86+). Potency values are reported for the more potent atropisomer in the mouse CD69 assay.

d

n = 1.