Table 5. Rat and Dog Pharmacokinetic Data Following Oral and IV Administration of 27.
| species | Cl (mL/min/kg) | Vss (L/kg) | IV T1/2 (h) | F (%) | oral Cmax (μM) | Tmax (h) | 
|---|---|---|---|---|---|---|
| rat | 39.6 ± 6.4 | 1.0 ± 0.1 | 0.3 ± 0.0 | 29.7 ± 4.5 | 0.6 ± 0.1 | 1.0 ± 0.0 | 
| dog | 8 ± 3 | 1.1 ± 0.2 | 1.9 ± 0.4 | 68 ± 21 | 1.5 ± 0.3 | 0.8 ± 0.3 |