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. 2021 Apr 5;12(5):782–790. doi: 10.1021/acsmedchemlett.1c00044

Table 5. Rat and Dog Pharmacokinetic Data Following Oral and IV Administration of 27.

species Cl (mL/min/kg) Vss (L/kg) IV T1/2 (h) F (%) oral Cmax (μM) Tmax (h)
rat 39.6 ± 6.4 1.0 ± 0.1 0.3 ± 0.0 29.7 ± 4.5 0.6 ± 0.1 1.0 ± 0.0
dog 8 ± 3 1.1 ± 0.2 1.9 ± 0.4 68 ± 21 1.5 ± 0.3 0.8 ± 0.3