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Reagents and conditions: (i) LiAlH4, THF, 0 °C to rt, 2–3 h; (ii) PDC, 4 Å molecular sieves or activated MnO2, CH2Cl2, rt, 12 h, 17–54% over two steps; (iii) cyclooctylamine, Na(OAc)3BH, acetic acid, THF, rt, 12 h, 10–92%.
