Skip to main content
. 2020 Nov 16;12(5):704–712. doi: 10.1021/acsmedchemlett.0c00588

Table 3. Solubility and PAMPA Permeability Profiles of Selected Series I–VI Analogsc.

graphic file with name ml0c00588_0009.jpg

a

Multiscreen filter plates (Millipore), 24 h agitation, pH 7.4, 25 °C.

b

Pe measures the rate at which a molecule crosses a membrane or lipid bilayer. Multiscreen-IP PAMPA assay donor/receiver plates (Millipore), 1% lecithin in dodecane as barrier, 18 h agitation, pH 7.4, 25 °C. Pe of propranolol determined under similar conditions was 11.9 ± 0.8.

c

Solubility and Pe values are mean (SD) from 3 separate determinations.