Table 2. Growth-Inhibitory Activities of Thiazolides in the HEK 293T and HeLa Cell Linesa.
| HEK
293T cell growth inhibition % (48 h) |
||||
|---|---|---|---|---|
| compd | IC50 (μM, 20 h) STAT3 pathway in HEK-Blue IL-6 cells | IC50 (μM, 48 h) HeLa cell growth | 50 μM | 10 μM |
| NTZ | 9.8 ± 0.2 | 35.0 ± 0.1 | 24.4 ± 1.0 | –3.3 ± 4.6 |
| TIZ | 8.9 ± 0.3 | 29.8 ± 1.5 | 21.6 ± 3.8 | –5.7 ± 4.3 |
| 9 | 4.6 ± 0.3 | 20.5 ± 4.4 | 21.2 ± 1.8 | –1.0 ± 5.8 |
| 10 | 2.3 ± 0.08 | 16.4 ± 1.5 | 24.9 ± 03 | 11.0 ± 1.8 |
| 11 | 3.6 ± 0.3 | 17.7 ± 6.4 | 25.8 ± 4.1 | –4.3 ± 2.9 |
| 13 | 3.0 ± 1.1 | 11.1 ± 1.7 | –0.2 ± 3.4 | –5.5 ± 3.3 |
| 14 | 1.5 ± 0.3 | 7.9 ± 2.1 | 21.0 ± 2.4 | 8.5 ± 3.6 |
| 15 | 0.7 ± 0.1 | 2.7 ± 1.1 | 38.3 ± 0.9 | 12.8 ± 2.7 |
| 16 | 2.5 ± 0.5 | 9.9 ± 1.7 | 30.8 ± 3.0 | 5.1 ± 3.0 |
| 24 | 0.8 ± 0.04 | 3.3 ± 0.8 | 19.1 ± 3.7 | 8.0 ± 4.6 |
| WP1066 | 2.5 ± 0.7 | 4.2 ± 0.2 | 97.2 ± 0.2 | 79.9 ± 6.8 |
a
All of the values are averages of three independent experiments.