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. 2021 May 13;9:663535. doi: 10.3389/fcell.2021.663535

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Copyright © 2021 Pavón-Romero, Serrano-Pérez, García-Sánchez, Ramírez-Jiménez and Terán.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nociceptin/orphanin FQ-N/OFQ. Neurons and lymphocytes produces this NP. The coupling with its receptor (NOP) decreases TCD4 + population, Th2 profile synthesis, the eosinophil chemotaxis as well as its activation, and the airway hyperresponsiveness (AHR) induced by ACh.