Table 2. Brain Uptakes of Radioactivity after Intravenous Injection of Radioiodinated BIPM and PIP Derivatives in Normal Mice^a and the Ratios of Their Radioactivity Accumulations (2 min/30 min).

	% ID/g in the brain
compd	2 min	10 min	30 min	60 min	2 min/30 min ratio
[125I]27 ([125I]BIPM-NHMe)	5.50 ± 0.41	0.85 ± 0.08	0.18 ± 0.02	0.13 ± 0.03	30.5
[125I]28 ([125I]BIPM-NHEt)	3.98 ± 0.18	0.83 ± 0.13	0.22 ± 0.05	0.11 ± 0.01	18.1
[125I]29 ([125I]BIPM-NHPr)	3.99 ± 0.63	0.88 ± 0.04	0.22 ± 0.02	0.09 ± 0.01	18.1
[125I]39 ([125I]BIPM-NEt2)	3.85 ± 0.39	1.25 ± 0.20	0.29 ± 0.04	0.12 ± 0.02	13.3
[125I]BIPM-NMe2b	5.66 ± 0.34	1.00 ± 0.09	0.19 ± 0.04	0.10 ± 0.01	29.7
[125I]30 ([125I]PIP-NHMe)	6.62 ± 0.84	1.73 ± 0.13	0.17 ± 0.01	0.10 ± 0.02	38.9
[125I]31 ([125I]PIP-NHEt)	6.86 ± 0.96	1.97 ± 0.17	0.24 ± 0.03	0.08 ± 0.01	28.6
[125I]32 ([125I]PIP-NHPr)	4.84 ± 0.39	1.10 ± 0.13	0.21 ± 0.00	0.10 ± 0.01	23.0
[125I]40 ([125I]PIP-NEt2)	4.54 ± 0.48	1.55 ± 0.26	0.23 ± 0.01	0.13 ± 0.01	19.7
[125I]PIP-NMe2b	5.73 ± 0.66	1.40 ± 0.32	0.21 ± 0.01	0.14 ± 0.02	27.3

^aEach value represents the mean ± SD of five animals.

^bThe data were reported previously.¹⁷