Table 1. Composition of LNP Was 10% mol DSPC, 50% mol CIL, 38.5% mol Cholesterol, 1.5% mol DMPE-PEG, 0.015% mol mRNA; Four Samples (Named MCH, MCHPC, MMO, MMC) Were Prepared with Different Levels of Deuteration in mol % in Phosphate Buffer Saline pH 7.4.
| % deuterated component |
||||
|---|---|---|---|---|
| MCH | MCHPC | MMO | MMC | |
| cholesterol | 100 | 100 | 42a | 0 |
| DSPC | 0 | 32 | 37 | 0 |
| MC3 (CIL) | 0 | 0 | 42 | 100 |
a
Here d-cholesterol (average 87% D) was used instead of d-cholesterol (average 89% D).