Table 2. Structural Information on mRNA-LNPs As Determined by SANS^a.

	MCH	MCHPC	MMO	MMC	average and SD
core radius/nm	26.4 ± 0.1	26.7 ± 0.1	b	31.0 ± 0.9	28 ± 3
shell thickness/nm	5.0 ± 0.1	6.9 ± 0.1	b	5.1 ± 0.3	6 ± 1
total radius/nm	31.4 ± 0.2	33.6 ± 0.2	31.5 ± 0.1	36 ± 1	33 ± 2
core solvent fraction (v/v%)	23 ± 1	17 ± 1	b	13 ± 3	18 ± 5
core volume/nm3	77 070	79 730	b	124 800
shell volume/nm3	52 610	79 160	b	70 640
total volume/nm3	129 680	158 890	123 600	195 430
hydrodynamic radius (DLS)/nmc	43 ± 1	44 ± 1	41 ± 1	43 ± 1

^aLNPs were formulated according to the molar composition stated in Table 1.

^bThese parameters cannot be assessed in MMO due to lack of contrast between shell and core in the experimental conditions used.

^cIntensity averaged.