Figure 5.

In vivo biodistribution and safety of biomimetic NP. Increasing the protein content on NPs was well tolerated and resulted in a different biodistribution in vivo. Mice were administrated with NP groups via IV injection. Mice were euthanized after either 8 h (LLI model) (A) or 24 h hours (TNBC model) (B), and the organs were collected and imaged. Tissue sections of the liver, spleen, lungs, and kidneys were prepared for H&E staining (C). Scale bar = 100 μm. Results are shown as mean ± SEM. One-way ANOVA followed by Tukey’s multiple comparison test were used to determine statistical probabilities. P value ≤0.05 among means was considered as statistically significant.