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Quality assessment of included studies.
| Studies | Description of randomization | Appropriate method for randomization | Description of double-blind | Appropriate method for double-blinding | Description of withdrawals and dropouts | Jadad scores |
|---|---|---|---|---|---|---|
| Pace 2003 | 1 | 0 | 0 | 0 | 1 | 2 |
| Argyriou 2005 | 1 | 1 | 0 | 0 | 1 | 3 |
| Argyriou 2006 | 1 | 1 | 0 | 0 | 1 | 3 |
| Argyriou 2006 | 1 | 1 | 0 | 0 | 1 | 3 |
| Pace 2010 | 1 | 1 | 1 | 1 | 1 | 5 |
| Kottschade 2011 | 1 | 1 | 1 | 1 | 1 | 5 |
| Afonseca 2013 | 1 | 1 | 1 | 1 | 1 | 5 |
| Salehi 2015 | 1 | 1 | 0 | 0 | 1 | 3 |
| Anoushirvani 2018 | 1 | 1 | 0 | 0 | 1 | 3 |
